SCOPUS BIOPHARMA INC

Ticker: SCPS CUSIP: 809171101 Class: Equity

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021

Shares 30,403 Value ($000) $50 Avg Close $3.03 Range $1.58 - $4.28

Q2 2021

Shares 31,416 Value ($000) $224 Avg Close $7.12 Range $5.13 - $19.95

Q1 2021

Shares 42,645 Value ($000) $360 Avg Close $10.46 Range $7.20 - $15.59

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2021	30,403	$50	$3.03	$1.58 - $4.28
Q2 2021	31,416	$224	$7.12	$5.13 - $19.95
Q1 2021	42,645	$360	$10.46	$7.20 - $15.59