CARTESIAN THERAPEUTICS INC

Ticker: RNAC CUSIP: 816212302 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 91,278 Value ($000) $658 Avg Close $8.09 Range $5.98 - $10.48

Q1 2025

Shares 11,015 Value ($000) $145 Avg Close $17.87 Range $13.02 - $20.12

Q4 2024

Shares 11,812 Value ($000) $212 Avg Close $20.25 Range $15.47 - $26.50

Q3 2024

Shares 12,911 Value ($000) $208 Avg Close $15.62 Range $12.48 - $28.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	91,278	$658	$8.09	$5.98 - $10.48
Q1 2025	11,015	$145	$17.87	$13.02 - $20.12
Q4 2024	11,812	$212	$20.25	$15.47 - $26.50
Q3 2024	12,911	$208	$15.62	$12.48 - $28.83