SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

PRICE T ROWE ASSOCIATES INC /MD/'s Holding History (CIK: 0000080255)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 1,247,008 Value ($000) $217,029 Avg Close — Range —
Q3 2018
Shares 1,845,264 Value ($000) $334,491 Avg Close — Range —
Q2 2018
Shares 1,955,356 Value ($000) $330,064 Avg Close — Range —
Q1 2018
Shares 3,164,889 Value ($000) $472,803 Avg Close — Range —
Q4 2017
Shares 3,422,003 Value ($000) $530,821 Avg Close — Range —
Q3 2017
Shares 3,829,386 Value ($000) $586,432 Avg Close — Range —
Q2 2017
Shares 4,045,055 Value ($000) $668,526 Avg Close — Range —
Q1 2017
Shares 3,465,083 Value ($000) $603,721 Avg Close — Range —
Q4 2016
Shares 4,001,241 Value ($000) $681,731 Avg Close — Range —
Q3 2016
Shares 4,781,923 Value ($000) $927,024 Avg Close — Range —
Q2 2016
Shares 3,979,512 Value ($000) $732,549 Avg Close — Range —
Q1 2016
Shares 2,396,997 Value ($000) $412,044 Avg Close — Range —
Q4 2015
Shares 1,676,487 Value ($000) $343,680 Avg Close — Range —
Q3 2015
Shares 1,666,021 Value ($000) $341,917 Avg Close — Range —
Q2 2015
Shares 2,419,585 Value ($000) $584,306 Avg Close — Range —
Q1 2015
Shares 1,478,092 Value ($000) $353,693 Avg Close — Range —
Q4 2014
Shares 46,877 Value ($000) $9,963 Avg Close — Range —
Q3 2014
Shares 1,950 Value ($000) $505 Avg Close — Range —
Q2 2014
Shares 14,265 Value ($000) $3,359 Avg Close — Range —
Q1 2014
Shares 14,565 Value ($000) $2,163 Avg Close — Range —
Q4 2013
Shares 268,997 Value ($000) $38,007 Avg Close — Range —
Q3 2013
Shares 271,097 Value ($000) $32,502 Avg Close — Range —
Q2 2013
Shares 271,297 Value ($000) $25,803 Avg Close — Range —