SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

ESSEX INVESTMENT MANAGEMENT CO LLC's Holding History (CIK: 0000201772)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 7,310 Value ($000) $1,346 Avg Close — Range —
Q1 2016
Shares 2,866 Value ($000) $493 Avg Close — Range —
Q4 2015
Shares 3,477 Value ($000) $713 Avg Close — Range —
Q3 2015
Shares 2,866 Value ($000) $588 Avg Close — Range —
Q2 2015
Shares 2,866 Value ($000) $692 Avg Close — Range —
Q1 2015
Shares 3,096 Value ($000) $741 Avg Close — Range —
Q4 2014
Shares 1,586 Value ($000) $337 Avg Close — Range —