SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 1,566,425 Value ($000) $272,621 Avg Close — Range —
Q3 2018
Shares 1,210,082 Value ($000) $219,350 Avg Close — Range —
Q2 2018
Shares 1,259,216 Value ($000) $212,555 Avg Close — Range —
Q1 2018
Shares 1,779,313 Value ($000) $265,810 Avg Close — Range —
Q4 2017
Shares 2,227,221 Value ($000) $345,486 Avg Close — Range —
Q3 2017
Shares 2,325,064 Value ($000) $356,060 Avg Close — Range —
Q2 2017
Shares 1,569,875 Value ($000) $259,454 Avg Close — Range —
Q1 2017
Shares 1,839,541 Value ($000) $320,503 Avg Close — Range —
Q4 2016
Shares 2,113,353 Value ($000) $360,072 Avg Close — Range —
Q3 2016
Shares 2,300,998 Value ($000) $446,071 Avg Close — Range —
Q2 2016
Shares 2,663,506 Value ($000) $490,297 Avg Close — Range —
Q1 2016
Shares 1,426,406 Value ($000) $245,200 Avg Close — Range —
Q4 2015
Shares 1,572,954 Value ($000) $322,455 Avg Close — Range —
Q3 2015
Shares 2,606,948 Value ($000) $535,025 Avg Close — Range —
Q2 2015
Shares 3,453,171 Value ($000) $833,906 Avg Close — Range —
Q1 2015
Shares 4,049,021 Value ($000) $968,890 Avg Close — Range —
Q4 2014
Shares 4,429,129 Value ($000) $941,367 Avg Close — Range —
Q3 2014
Shares 3,065,200 Value ($000) $794,040 Avg Close — Range —
Q2 2014
Shares 3,419,600 Value ($000) $805,281 Avg Close — Range —
Q1 2014
Shares 2,212,700 Value ($000) $328,653 Avg Close — Range —
Q4 2013
Shares 2,207,000 Value ($000) $311,828 Avg Close — Range —
Q3 2013
Shares 1,452,800 Value ($000) $174,176 Avg Close — Range —
Q2 2013
Shares 604,600 Value ($000) $57,504 Avg Close — Range —