SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 500,000 Value ($000) $87,020 Avg Close — Range —
Q3 2018
Shares 3,200,000 Value ($000) $580,064 Avg Close — Range —
Q2 2018
Shares 2,000,000 Value ($000) $337,600 Avg Close — Range —
Q1 2018
Shares 150,000 Value ($000) $22,409 Avg Close — Range —
Q2 2015
Shares 28,000 Value ($000) $6,762 Avg Close — Range —
Q3 2014
Shares 3,267,220 Value ($000) $846,373 Avg Close — Range —
Q1 2014
Shares 114,171 Value ($000) $16,958 Avg Close — Range —
Q4 2013
Shares 50,671 Value ($000) $7,159 Avg Close — Range —