SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017
Shares 11,010 Value ($000) $1,686 Avg Close — Range —
Q1 2016
Shares 10,794 Value ($000) $1,855 Avg Close — Range —
Q3 2015
Shares 61,624 Value ($000) $12,647 Avg Close — Range —
Q1 2015
Shares 1,713 Value ($000) $410 Avg Close — Range —
Q4 2014
Shares 114,093 Value ($000) $24,249 Avg Close — Range —
Q3 2014
Shares 321,876 Value ($000) $83,382 Avg Close — Range —
Q1 2014
Shares 125,308 Value ($000) $18,612 Avg Close — Range —
Q4 2013
Shares 14,739 Value ($000) $2,082 Avg Close — Range —
Q2 2013
Shares 4,448 Value ($000) $423 Avg Close — Range —