SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

PERCEPTIVE ADVISORS LLC's Holding History (CIK: 0001224962)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 41,000 Value ($000) $8,415 Avg Close — Range —
Q2 2015
Shares 40,000 Value ($000) $9,660 Avg Close — Range —
Q1 2015
Shares 30,000 Value ($000) $7,179 Avg Close — Range —
Q4 2014
Shares 10,000 Value ($000) $2,125 Avg Close — Range —
Q2 2014
Shares 90,000 Value ($000) $21,194 Avg Close — Range —
Q1 2014
Shares 30,000 Value ($000) $4,456 Avg Close — Range —
Q4 2013
Shares 10,000 Value ($000) $1,413 Avg Close — Range —
Q2 2013
Shares 80,800 Value ($000) $7,685 Avg Close — Range —