SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

CLOUGH CAPITAL PARTNERS L P's Holding History (CIK: 0001276144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 88,437 Value ($000) $15,068 Avg Close — Range —
Q3 2016
Shares 49,600 Value ($000) $9,615 Avg Close — Range —
Q2 2016
Shares 38,200 Value ($000) $7,032 Avg Close — Range —
Q1 2016
Shares 72,900 Value ($000) $12,532 Avg Close — Range —
Q1 2015
Shares 84,308 Value ($000) $20,174 Avg Close — Range —
Q4 2014
Shares 125,700 Value ($000) $26,716 Avg Close — Range —
Q2 2014
Shares 62,600 Value ($000) $14,742 Avg Close — Range —