SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 47,938 Value ($000) $8,343 Avg Close — Range —
Q3 2018
Shares 192,738 Value ($000) $34,938 Avg Close — Range —
Q2 2018
Shares 191,200 Value ($000) $32,275 Avg Close — Range —
Q1 2018
Shares 191,200 Value ($000) $28,563 Avg Close — Range —
Q4 2017
Shares 135,800 Value ($000) $21,065 Avg Close — Range —
Q3 2017
Shares 130,200 Value ($000) $19,939 Avg Close — Range —
Q2 2017
Shares 130,200 Value ($000) $21,518 Avg Close — Range —
Q1 2017
Shares 130,200 Value ($000) $22,685 Avg Close — Range —
Q4 2016
Shares 124,100 Value ($000) $21,144 Avg Close — Range —
Q3 2016
Shares 123,200 Value ($000) $23,884 Avg Close — Range —
Q2 2016
Shares 119,300 Value ($000) $21,961 Avg Close — Range —
Q1 2016
Shares 106,100 Value ($000) $18,239 Avg Close — Range —
Q4 2015
Shares 104,700 Value ($000) $21,464 Avg Close — Range —
Q3 2015
Shares 104,700 Value ($000) $21,488 Avg Close — Range —
Q2 2015
Shares 98,300 Value ($000) $23,738 Avg Close — Range —
Q1 2015
Shares 95,000 Value ($000) $22,733 Avg Close — Range —
Q4 2014
Shares 85,600 Value ($000) $18,193 Avg Close — Range —
Q3 2014
Shares 63,700 Value ($000) $16,501 Avg Close — Range —
Q2 2014
Shares 63,700 Value ($000) $15,001 Avg Close — Range —
Q1 2014
Shares 1,800 Value ($000) $267 Avg Close — Range —