SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 956,396 Value ($000) $166,452 Avg Close — Range —
Q3 2018
Shares 497,422 Value ($000) $90,168 Avg Close — Range —
Q2 2018
Shares 356,002 Value ($000) $60,093 Avg Close — Range —
Q1 2018
Shares 266,233 Value ($000) $39,773 Avg Close — Range —
Q4 2017
Shares 392,438 Value ($000) $60,875 Avg Close — Range —
Q3 2017
Shares 484,392 Value ($000) $74,112 Avg Close — Range —
Q2 2017
Shares 538,704 Value ($000) $88,886 Avg Close — Range —
Q1 2017
Shares 505,891 Value ($000) $88,025 Avg Close — Range —
Q4 2016
Shares 1,035,554 Value ($000) $176,438 Avg Close — Range —
Q3 2016
Shares 898,338 Value ($000) $174,152 Avg Close — Range —
Q2 2016
Shares 1,055,873 Value ($000) $194,365 Avg Close — Range —
Q1 2016
Shares 29,339 Value ($000) $5,043 Avg Close — Range —
Q4 2015
Shares 38,198 Value ($000) $7,831 Avg Close — Range —
Q4 2014
Shares 9,195 Value ($000) $1,954 Avg Close — Range —
Q3 2014
Shares 2,017 Value ($000) $523 Avg Close — Range —
Q2 2014
Shares 42,889 Value ($000) $10,100 Avg Close — Range —
Q1 2014
Shares 163,778 Value ($000) $24,326 Avg Close — Range —