SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

Choate Investment Advisors's Holding History (CIK: 0001399794)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 2,043 Value ($000) $396,056 Avg Close — Range —
Q2 2016
Shares 2,846 Value ($000) $523,892 Avg Close — Range —