SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 3,065 Value ($000) $533 Avg Close — Range —
Q3 2018
Shares 2,236 Value ($000) $405 Avg Close — Range —
Q2 2018
Shares 11,185 Value ($000) $1,888 Avg Close — Range —
Q1 2018
Shares 14,498 Value ($000) $2,166 Avg Close — Range —
Q4 2016
Shares 2,146 Value ($000) $366 Avg Close — Range —
Q2 2016
Shares 2,454 Value ($000) $452 Avg Close — Range —