SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 1,919 Value ($000) $334 Avg Close — Range —
Q3 2018
Shares 1,940 Value ($000) $352 Avg Close — Range —
Q2 2018
Shares 1,940 Value ($000) $327 Avg Close — Range —
Q1 2018
Shares 1,919 Value ($000) $287 Avg Close — Range —
Q4 2017
Shares 1,919 Value ($000) $298 Avg Close — Range —
Q3 2017
Shares 316,501 Value ($000) $48,469 Avg Close — Range —
Q1 2017
Shares 1,919 Value ($000) $334 Avg Close — Range —
Q4 2016
Shares 3,911 Value ($000) $666 Avg Close — Range —
Q3 2016
Shares 1,919 Value ($000) $372 Avg Close — Range —
Q2 2016
Shares 45,076 Value ($000) $8,298 Avg Close — Range —
Q3 2015
Shares 1,000 Value ($000) $205 Avg Close — Range —
Q4 2014
Shares 91,500 Value ($000) $19,447 Avg Close — Range —
Q3 2014
Shares 900 Value ($000) $233 Avg Close — Range —