SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 5,420 Value ($000) $943 Avg Close — Range —
Q1 2018
Shares 100 Value ($000) $14 Avg Close — Range —
Q4 2017
Shares 10,599 Value ($000) $1,644 Avg Close — Range —
Q3 2017
Shares 10,276 Value ($000) $1,573 Avg Close — Range —
Q1 2017
Shares 5,016 Value ($000) $873 Avg Close — Range —
Q3 2016
Shares 7,601 Value ($000) $1,473 Avg Close — Range —
Q2 2016
Shares 20,289 Value ($000) $3,734 Avg Close — Range —
Q1 2016
Shares 4,752 Value ($000) $816 Avg Close — Range —