SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

JGP Global Gestao de Recursos Ltda.'s Holding History (CIK: 0001536562)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 9,183 Value ($000) $1,883 Avg Close — Range —
Q3 2015
Shares 8,715 Value ($000) $1,789 Avg Close — Range —
Q2 2015
Shares 7,395 Value ($000) $1,786 Avg Close — Range —
Q1 2015
Shares 7,011 Value ($000) $1,678 Avg Close — Range —
Q4 2014
Shares 21,246 Value ($000) $4,516 Avg Close — Range —