SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

SUVRETTA CAPITAL MANAGEMENT, LLC's Holding History (CIK: 0001569064)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016

Shares 374,200 Value ($000) $72,542 Avg Close — Range —

Q2 2016

Shares 670,301 Value ($000) $123,389 Avg Close — Range —

Q1 2015

Shares 258,100 Value ($000) $61,761 Avg Close — Range —

Q2 2014

Shares 42,700 Value ($000) $10,055 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2016	374,200	$72,542	—	—
Q2 2016	670,301	$123,389	—	—
Q1 2015	258,100	$61,761	—	—
Q2 2014	42,700	$10,055	—	—