SHIRE PLC

CUSIP: 82481R106 Class: COMMON STOCK-FO

Aristotle Atlantic Partners, LLC's Holding History (CIK: 0001697267)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 19,322 Value ($000) $2,887 Avg Close — Range —
Q4 2017
Shares 18,386 Value ($000) $2,852 Avg Close — Range —