SHIRE PLC

CUSIP: 82481r106 Class: SPONSORED ADR

FRANKLIN STREET ADVISORS INC /NC's Holding History (CIK: 0001010873)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 5,817 Value ($000) $991 Avg Close — Range —
Q3 2016
Shares 5,695 Value ($000) $1,104 Avg Close — Range —
Q2 2016
Shares 5,697 Value ($000) $1,049 Avg Close — Range —
Q1 2016
Shares 5,500 Value ($000) $945 Avg Close — Range —
Q4 2015
Shares 5,500 Value ($000) $1,128 Avg Close — Range —
Q3 2015
Shares 5,500 Value ($000) $1,129 Avg Close — Range —
Q2 2015
Shares 5,500 Value ($000) $1,328 Avg Close — Range —
Q1 2015
Shares 5,500 Value ($000) $1,316 Avg Close — Range —
Q4 2014
Shares 5,500 Value ($000) $1,169 Avg Close — Range —
Q3 2014
Shares 5,500 Value ($000) $1,425 Avg Close — Range —
Q2 2014
Shares 5,500 Value ($000) $1,295 Avg Close — Range —
Q1 2014
Shares 5,500 Value ($000) $817 Avg Close — Range —
Q4 2013
Shares 5,500 Value ($000) $777 Avg Close — Range —
Q3 2013
Shares 5,500 Value ($000) $659 Avg Close — Range —
Q2 2013
Shares 5,500 Value ($000) $523 Avg Close — Range —