SIENNA BIOPHARMACEUTICALS IN

Ticker: SNNAQ CUSIP: 82622H108 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018

Shares 13,343 Value ($000) $203 Avg Close $16.98 Range $14.33 - $21.53

Q1 2018

Shares 12,335 Value ($000) $232 Avg Close $17.48 Range $13.37 - $20.99

Q4 2017

Shares 1,488 Value ($000) $27 Avg Close $21.15 Range $15.22 - $26.00

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2018	13,343	$203	$16.98	$14.33 - $21.53
Q1 2018	12,335	$232	$17.48	$13.37 - $20.99
Q4 2017	1,488	$27	$21.15	$15.22 - $26.00