SIENNA BIOPHARMACEUTICALS IN

Ticker: SNNAQ CUSIP: 82622H108 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2019

Shares 83,579 Value ($000) $17 Avg Close $0.68 Range $0.10 - $1.59

Q2 2019

Shares 161,367 Value ($000) $140 Avg Close $1.57 Range $0.83 - $2.47

Q1 2019

Shares 156,602 Value ($000) $363 Avg Close $2.71 Range $2.05 - $3.80

Q4 2018

Shares 64,074 Value ($000) $149 Avg Close $8.82 Range $2.23 - $15.18

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2019	83,579	$17	$0.68	$0.10 - $1.59
Q2 2019	161,367	$140	$1.57	$0.83 - $2.47
Q1 2019	156,602	$363	$2.71	$2.05 - $3.80
Q4 2018	64,074	$149	$8.82	$2.23 - $15.18