SIENNA BIOPHARMACEUTICALS IN

Ticker: SNNAQ CUSIP: 82622H108 Class: COM

CLOUGH CAPITAL PARTNERS L P's Holding History (CIK: 0001276144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018

Shares 136,228 Value ($000) $316 Avg Close $8.82 Range $2.23 - $15.18

Q3 2018

Shares 243,295 Value ($000) $3,606 Avg Close $15.89 Range $12.77 - $18.05

Q2 2018

Shares 292,695 Value ($000) $4,446 Avg Close $16.98 Range $14.33 - $21.53

Q1 2018

Shares 647,357 Value ($000) $12,157 Avg Close $17.48 Range $13.37 - $20.99

Q4 2017

Shares 785,309 Value ($000) $14,206 Avg Close $21.15 Range $15.22 - $26.00

Q3 2017

Shares 751,209 Value ($000) $16,421 Avg Close $21.95 Range $18.50 - $29.25

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2018	136,228	$316	$8.82	$2.23 - $15.18
Q3 2018	243,295	$3,606	$15.89	$12.77 - $18.05
Q2 2018	292,695	$4,446	$16.98	$14.33 - $21.53
Q1 2018	647,357	$12,157	$17.48	$13.37 - $20.99
Q4 2017	785,309	$14,206	$21.15	$15.22 - $26.00
Q3 2017	751,209	$16,421	$21.95	$18.50 - $29.25