SINGULAR GENOMICS SYSTEMS IN

CUSIP: 82933R100 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022
Shares 162,725 Value ($000) $622 Avg Close — Range —
Q1 2022
Shares 25,228 Value ($000) $159 Avg Close — Range —
Q3 2021
Shares 13,446 Value ($000) $150 Avg Close — Range —
Q2 2021
Shares 15,017 Value ($000) $413 Avg Close — Range —