SOPHIRIS BIO INC

CUSIP: 83578Q209 Class: FOREIGN CANADIAN

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019
Shares 247,000 Value ($000) $91 Avg Close — Range —
Q3 2019
Shares 247,000 Value ($000) $144 Avg Close — Range —
Q2 2019
Shares 247,000 Value ($000) $209 Avg Close — Range —
Q1 2019
Shares 247,000 Value ($000) $245 Avg Close — Range —
Q4 2018
Shares 247,000 Value ($000) $205 Avg Close — Range —
Q3 2018
Shares 247,000 Value ($000) $689 Avg Close — Range —
Q2 2018
Shares 247,000 Value ($000) $694 Avg Close — Range —
Q1 2018
Shares 247,000 Value ($000) $496 Avg Close — Range —
Q4 2017
Shares 247,000 Value ($000) $561 Avg Close — Range —
Q3 2017
Shares 247,000 Value ($000) $530 Avg Close — Range —
Q2 2017
Shares 247,000 Value ($000) $543 Avg Close — Range —
Q1 2017
Shares 247,000 Value ($000) $699 Avg Close — Range —
Q4 2016
Shares 247,000 Value ($000) $692 Avg Close — Range —
Q3 2016
Shares 247,000 Value ($000) $768 Avg Close — Range —
Q2 2016
Shares 494,000 Value ($000) $1,062 Avg Close — Range —
Q1 2016
Shares 494,000 Value ($000) $711 Avg Close — Range —
Q4 2015
Shares 494,000 Value ($000) $879 Avg Close — Range —
Q3 2015
Shares 191,600 Value ($000) $163 Avg Close — Range —
Q2 2015
Shares 191,600 Value ($000) $150 Avg Close — Range —
Q1 2015
Shares 191,600 Value ($000) $111 Avg Close — Range —
Q4 2014
Shares 191,600 Value ($000) $103 Avg Close — Range —
Q3 2014
Shares 292,900 Value ($000) $858 Avg Close — Range —
Q2 2014
Shares 292,900 Value ($000) $656 Avg Close — Range —
Q1 2014
Shares 292,900 Value ($000) $975 Avg Close — Range —
Q4 2013
Shares 292,900 Value ($000) $1,084 Avg Close — Range —
Q3 2013
Shares 55,000 Value ($000) $257 Avg Close — Range —