SOPHIRIS BIO INC

CUSIP: 83578Q209 Class: FOREIGN CANADIAN

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2017
Shares 16,333 Value ($000) $37 Avg Close — Range —
Q1 2017
Shares 11,622 Value ($000) $33 Avg Close — Range —