SORRENTO THERAPEUTICS INC

Ticker: SRNE CUSIP: 83587F202 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 302,015 Value ($000) $268 Avg Close $1.33 Range $0.74 - $1.89

Q3 2022

Shares 302,015 Value ($000) $474 Avg Close $2.27 Range $1.50 - $3.09

Q2 2022

Shares 302,015 Value ($000) $607 Avg Close $1.73 Range $1.15 - $2.48

Q1 2022

Shares 1,088,700 Value ($000) $2,537 Avg Close $3.12 Range $1.96 - $4.99

Q1 2015

Shares 73,035 Value ($000) $844 Avg Close $11.57 Range $8.27 - $14.30

Q4 2014

Shares 31,877 Value ($000) $321 Avg Close $5.07 Range $3.10 - $10.80

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	302,015	$268	$1.33	$0.74 - $1.89
Q3 2022	302,015	$474	$2.27	$1.50 - $3.09
Q2 2022	302,015	$607	$1.73	$1.15 - $2.48
Q1 2022	1,088,700	$2,537	$3.12	$1.96 - $4.99
Q1 2015	73,035	$844	$11.57	$8.27 - $14.30
Q4 2014	31,877	$321	$5.07	$3.10 - $10.80