SPRUCE BIOSCIENCES INC

CUSIP: 85209E109 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021
Shares 240,511 Value ($000) $2,696 Avg Close — Range —
Q1 2021
Shares 290,511 Value ($000) $4,822 Avg Close — Range —
Q4 2020
Shares 290,511 Value ($000) $7,062 Avg Close — Range —