SPRUCE BIOSCIENCES INC

CUSIP: 85209E109 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025
Shares 20,545 Value ($000) $6 Avg Close — Range —
Q4 2024
Shares 20,616 Value ($000) $9 Avg Close — Range —
Q3 2024
Shares 23,368 Value ($000) $11 Avg Close — Range —
Q2 2024
Shares 28,584 Value ($000) $15 Avg Close — Range —
Q1 2024
Shares 123,013 Value ($000) $97 Avg Close — Range —
Q4 2023
Shares 134,357 Value ($000) $394 Avg Close — Range —
Q3 2023
Shares 147,357 Value ($000) $333 Avg Close — Range —
Q2 2023
Shares 228,130 Value ($000) $490 Avg Close — Range —
Q1 2023
Shares 163,165 Value ($000) $361 Avg Close — Range —
Q3 2021
Shares 29,392 Value ($000) $177 Avg Close — Range —
Q2 2021
Shares 11,975 Value ($000) $134 Avg Close — Range —