SPRUCE BIOSCIENCES INC

CUSIP: 85209E109 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025
Shares 47,686 Value ($000) $14 Avg Close — Range —
Q1 2024
Shares 26,016 Value ($000) $20 Avg Close — Range —
Q4 2021
Shares 28,691 Value ($000) $128 Avg Close — Range —