SPRUCE BIOSCIENCES INC

CUSIP: 85209E109 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025
Shares 12,200 Value ($000) $4 Avg Close — Range —
Q4 2024
Shares 13,800 Value ($000) $6 Avg Close — Range —
Q3 2024
Shares 27,100 Value ($000) $13 Avg Close — Range —
Q2 2024
Shares 45,700 Value ($000) $24 Avg Close — Range —
Q1 2024
Shares 90,300 Value ($000) $71 Avg Close — Range —
Q4 2023
Shares 95,600 Value ($000) $280 Avg Close — Range —
Q3 2023
Shares 96,300 Value ($000) $218 Avg Close — Range —
Q2 2023
Shares 240,000 Value ($000) $516 Avg Close — Range —
Q1 2023
Shares 37,600 Value ($000) $83 Avg Close — Range —
Q3 2021
Shares 19,200 Value ($000) $115 Avg Close — Range —