SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639118 Class: *W EXP 12/06/201

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q3 2014
Shares 375,000 Value ($000) $311 Avg Close — Range —
Q2 2014
Shares 375,000 Value ($000) $495 Avg Close — Range —
Q1 2014
Shares 375,000 Value ($000) $713 Avg Close — Range —
Q4 2013
Shares 375,000 Value ($000) $806 Avg Close — Range —
Q3 2013
Shares 375,000 Value ($000) $600 Avg Close — Range —
Q2 2013
Shares 375,000 Value ($000) $679 Avg Close — Range —