SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

PRICE T ROWE ASSOCIATES INC /MD/'s Holding History (CIK: 0000080255)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017
Shares 50,707 Value ($000) $147 Avg Close — Range —
Q2 2017
Shares 50,607 Value ($000) $225 Avg Close — Range —
Q1 2017
Shares 43,207 Value ($000) $201 Avg Close — Range —
Q4 2016
Shares 43,107 Value ($000) $263 Avg Close — Range —
Q3 2016
Shares 43,107 Value ($000) $238 Avg Close — Range —
Q2 2016
Shares 88,600 Value ($000) $337 Avg Close — Range —
Q1 2016
Shares 51,600 Value ($000) $142 Avg Close — Range —
Q4 2015
Shares 35,700 Value ($000) $202 Avg Close — Range —
Q3 2015
Shares 47,000 Value ($000) $249 Avg Close — Range —
Q2 2015
Shares 47,000 Value ($000) $390 Avg Close — Range —
Q1 2015
Shares 47,000 Value ($000) $217 Avg Close — Range —
Q4 2014
Shares 47,000 Value ($000) $143 Avg Close — Range —
Q3 2014
Shares 70,000 Value ($000) $195 Avg Close — Range —
Q2 2014
Shares 39,800 Value ($000) $162 Avg Close — Range —
Q1 2014
Shares 21,500 Value ($000) $114 Avg Close — Range —
Q3 2013
Shares 25,000 Value ($000) $114 Avg Close — Range —
Q2 2013
Shares 22,000 Value ($000) $95 Avg Close — Range —