SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 1,595,200 Value ($000) $8,789 Avg Close — Range —
Q4 2014
Shares 1,688,356 Value ($000) $5,149 Avg Close — Range —
Q3 2014
Shares 2,470,956 Value ($000) $6,882 Avg Close — Range —
Q2 2014
Shares 2,470,956 Value ($000) $10,057 Avg Close — Range —
Q1 2014
Shares 2,653,656 Value ($000) $14,091 Avg Close — Range —
Q4 2013
Shares 2,653,656 Value ($000) $14,940 Avg Close — Range —
Q3 2013
Shares 3,453,656 Value ($000) $15,783 Avg Close — Range —
Q2 2013
Shares 3,573,056 Value ($000) $15,436 Avg Close — Range —