SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

FIRST MANHATTAN CO. LLC.'s Holding History (CIK: 0000728083)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 8,995 Value ($000) $54 Avg Close — Range —
Q3 2016
Shares 8,995 Value ($000) $49 Avg Close — Range —