SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

PERCEPTIVE ADVISORS LLC's Holding History (CIK: 0001224962)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018

Shares 100,000 Value ($000) $183 Avg Close — Range —

Q1 2017

Shares 978,100 Value ($000) $4,558 Avg Close — Range —

Q4 2016

Shares 490,300 Value ($000) $2,986 Avg Close — Range —

Q3 2016

Shares 89,127 Value ($000) $491 Avg Close — Range —

Q3 2015

Shares 226,000 Value ($000) $1,198 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2018	100,000	$183	—	—
Q1 2017	978,100	$4,558	—	—
Q4 2016	490,300	$2,986	—	—
Q3 2016	89,127	$491	—	—
Q3 2015	226,000	$1,198	—	—