SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 67,100 Value ($000) $356 Avg Close — Range —
Q4 2014
Shares 973,245 Value ($000) $2,968 Avg Close — Range —
Q3 2014
Shares 973,245 Value ($000) $2,710 Avg Close — Range —
Q2 2014
Shares 1,758,271 Value ($000) $7,156 Avg Close — Range —
Q1 2014
Shares 1,758,271 Value ($000) $9,336 Avg Close — Range —
Q4 2013
Shares 2,608,271 Value ($000) $14,685 Avg Close — Range —
Q3 2013
Shares 2,608,271 Value ($000) $11,920 Avg Close — Range —
Q2 2013
Shares 2,608,271 Value ($000) $11,268 Avg Close — Range —