SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

DAFNA Capital Management LLC's Holding History (CIK: 0001389933)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 34,000 Value ($000) $207 Avg Close — Range —
Q3 2016
Shares 274,563 Value ($000) $1,513 Avg Close — Range —
Q2 2016
Shares 319,563 Value ($000) $1,214 Avg Close — Range —
Q1 2016
Shares 294,563 Value ($000) $813 Avg Close — Range —
Q4 2015
Shares 294,563 Value ($000) $1,670 Avg Close — Range —
Q3 2015
Shares 296,563 Value ($000) $1,572 Avg Close — Range —
Q2 2015
Shares 317,563 Value ($000) $2,636 Avg Close — Range —