SYNERGY PHARMACEUTICALS DEL

CUSIP: 871639308 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 13,760 Value ($000) $24 Avg Close — Range —
Q1 2017
Shares 16,813 Value ($000) $78 Avg Close — Range —