SYROS PHARMACEUTICALS INC

CUSIP: 87184Q107 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 186,366 Value ($000) $222 Avg Close — Range —
Q4 2021
Shares 48,674 Value ($000) $159 Avg Close — Range —
Q3 2021
Shares 91,278 Value ($000) $408 Avg Close — Range —
Q2 2021
Shares 120,354 Value ($000) $656 Avg Close — Range —
Q1 2021
Shares 210,375 Value ($000) $1,574 Avg Close — Range —
Q4 2020
Shares 139,034 Value ($000) $1,509 Avg Close — Range —
Q3 2020
Shares 153,508 Value ($000) $1,357 Avg Close — Range —
Q2 2020
Shares 246,997 Value ($000) $2,633 Avg Close — Range —
Q4 2019
Shares 21,700 Value ($000) $150 Avg Close — Range —
Q1 2019
Shares 18,539 Value ($000) $169 Avg Close — Range —
Q4 2018
Shares 47,756 Value ($000) $266 Avg Close — Range —
Q3 2018
Shares 57,081 Value ($000) $680 Avg Close — Range —
Q4 2017
Shares 21,197 Value ($000) $206 Avg Close — Range —
Q3 2017
Shares 11,758 Value ($000) $173 Avg Close — Range —