TARGACEPT INC

CUSIP: 87611R306 Class: CMN

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 169,421 Value ($000) $446 Avg Close — Range —
Q3 2014
Shares 138,521 Value ($000) $350 Avg Close — Range —
Q2 2014
Shares 128,821 Value ($000) $581 Avg Close — Range —
Q1 2014
Shares 121,421 Value ($000) $576 Avg Close — Range —
Q4 2013
Shares 119,521 Value ($000) $497 Avg Close — Range —
Q3 2013
Shares 135,821 Value ($000) $722 Avg Close — Range —
Q2 2013
Shares 122,921 Value ($000) $524 Avg Close — Range —