TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 46,113 Value ($000) $165 Avg Close — Range —
Q1 2018
Shares 44,554 Value ($000) $137 Avg Close — Range —
Q4 2017
Shares 41,984 Value ($000) $264 Avg Close — Range —
Q3 2017
Shares 40,831 Value ($000) $279 Avg Close — Range —
Q2 2017
Shares 31,342 Value ($000) $224 Avg Close — Range —
Q1 2017
Shares 31,513 Value ($000) $290 Avg Close — Range —
Q4 2016
Shares 28,501 Value ($000) $115 Avg Close — Range —
Q3 2016
Shares 28,423 Value ($000) $109 Avg Close — Range —
Q2 2016
Shares 28,423 Value ($000) $122 Avg Close — Range —
Q1 2016
Shares 25,244 Value ($000) $111 Avg Close — Range —
Q4 2015
Shares 24,072 Value ($000) $242 Avg Close — Range —
Q3 2015
Shares 23,567 Value ($000) $176 Avg Close — Range —
Q2 2015
Shares 22,793 Value ($000) $1,081 Avg Close — Range —
Q1 2015
Shares 17,030 Value ($000) $624 Avg Close — Range —
Q4 2014
Shares 16,436 Value ($000) $653 Avg Close — Range —
Q3 2014
Shares 15,191 Value ($000) $303 Avg Close — Range —
Q2 2014
Shares 15,354 Value ($000) $207 Avg Close — Range —
Q1 2014
Shares 11,742 Value ($000) $128 Avg Close — Range —
Q4 2013
Shares 9,695 Value ($000) $131 Avg Close — Range —