TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 300,000 Value ($000) $14,232 Avg Close — Range —
Q1 2015
Shares 400,000 Value ($000) $14,656 Avg Close — Range —
Q4 2014
Shares 400,000 Value ($000) $15,884 Avg Close — Range —
Q3 2014
Shares 504,548 Value ($000) $10,066 Avg Close — Range —