TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019
Shares 584,340 Value ($000) $281 Avg Close — Range —
Q1 2019
Shares 749,155 Value ($000) $1,004 Avg Close — Range —
Q4 2018
Shares 785,950 Value ($000) $888 Avg Close — Range —
Q3 2018
Shares 510,006 Value ($000) $1,408 Avg Close — Range —
Q4 2017
Shares 64,413 Value ($000) $406 Avg Close — Range —
Q3 2017
Shares 17,100 Value ($000) $117 Avg Close — Range —
Q1 2017
Shares 94,328 Value ($000) $867 Avg Close — Range —
Q4 2016
Shares 11,550 Value ($000) $47 Avg Close — Range —
Q1 2016
Shares 153,179 Value ($000) $709 Avg Close — Range —
Q2 2015
Shares 66,690 Value ($000) $3,164 Avg Close — Range —
Q1 2015
Shares 77,687 Value ($000) $2,846 Avg Close — Range —