TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019
Shares 270,300 Value ($000) $130 Avg Close — Range —
Q1 2019
Shares 271,500 Value ($000) $364 Avg Close — Range —
Q4 2018
Shares 221,000 Value ($000) $250 Avg Close — Range —
Q3 2018
Shares 147,100 Value ($000) $406 Avg Close — Range —
Q3 2017
Shares 18,400 Value ($000) $126 Avg Close — Range —
Q2 2017
Shares 27,500 Value ($000) $196 Avg Close — Range —
Q1 2017
Shares 68,600 Value ($000) $630 Avg Close — Range —
Q4 2016
Shares 48,600 Value ($000) $196 Avg Close — Range —
Q3 2016
Shares 51,700 Value ($000) $198 Avg Close — Range —
Q2 2016
Shares 93,000 Value ($000) $400 Avg Close — Range —
Q1 2016
Shares 102,500 Value ($000) $475 Avg Close — Range —
Q4 2015
Shares 74,500 Value ($000) $747 Avg Close — Range —
Q3 2015
Shares 85,400 Value ($000) $637 Avg Close — Range —
Q2 2015
Shares 6,600 Value ($000) $313 Avg Close — Range —