TETRAPHASE PHARMACEUTICALS I

CUSIP: 88165N105 Class: COMMON STOCK

EDMOND DE ROTHSCHILD HOLDING S.A.'s Holding History (CIK: 0001649647)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019
Shares 210,000 Value ($000) $101 Avg Close — Range —
Q1 2019
Shares 210,000 Value ($000) $281 Avg Close — Range —
Q4 2018
Shares 110,000 Value ($000) $124 Avg Close — Range —
Q3 2018
Shares 110,000 Value ($000) $304 Avg Close — Range —
Q2 2018
Shares 110,000 Value ($000) $393 Avg Close — Range —
Q1 2018
Shares 40,000 Value ($000) $123 Avg Close — Range —