TIZIANA LIFE SCIENCES PLC

CUSIP: 88875G101 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020
Shares 22,300 Value ($000) $45 Avg Close — Range —
Q3 2020
Shares 27,400 Value ($000) $91 Avg Close — Range —