TOBIRA THERAPEUTICS INC

CUSIP: 88883P101 Class: COMMON

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 609 Value ($000) $24 Avg Close — Range —
Q2 2016
Shares 609 Value ($000) $8 Avg Close — Range —
Q1 2016
Shares 1,577 Value ($000) $13 Avg Close — Range —
Q4 2015
Shares 116 Value ($000) $1 Avg Close — Range —
Q3 2015
Shares 116 Value ($000) $1 Avg Close — Range —