TREVENA INC

CUSIP: 89532E109 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 785,000 Value ($000) $6,492 Avg Close — Range —
Q4 2015
Shares 800,000 Value ($000) $8,400 Avg Close — Range —
Q3 2015
Shares 800,000 Value ($000) $8,280 Avg Close — Range —
Q2 2015
Shares 1,400,000 Value ($000) $8,764 Avg Close — Range —
Q1 2015
Shares 1,400,000 Value ($000) $9,128 Avg Close — Range —
Q4 2014
Shares 1,400,000 Value ($000) $8,372 Avg Close — Range —
Q3 2014
Shares 800,000 Value ($000) $5,136 Avg Close — Range —
Q2 2014
Shares 800,000 Value ($000) $4,520 Avg Close — Range —
Q1 2014
Shares 800,000 Value ($000) $6,288 Avg Close — Range —