TREVENA INC

CUSIP: 89532E109 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 88,092 Value ($000) $13 Avg Close — Range —
Q2 2022
Shares 47,354 Value ($000) $20 Avg Close — Range —
Q1 2022
Shares 465,325 Value ($000) $256 Avg Close — Range —
Q4 2021
Shares 778,918 Value ($000) $454 Avg Close — Range —
Q3 2021
Shares 205,783 Value ($000) $253 Avg Close — Range —
Q2 2021
Shares 42,912 Value ($000) $73 Avg Close — Range —
Q1 2021
Shares 1,280,298 Value ($000) $2,292 Avg Close — Range —
Q4 2020
Shares 328,707 Value ($000) $703 Avg Close — Range —
Q2 2020
Shares 165,269 Value ($000) $248 Avg Close — Range —
Q4 2019
Shares 39,037 Value ($000) $33 Avg Close — Range —
Q3 2019
Shares 41,454 Value ($000) $40 Avg Close — Range —
Q2 2019
Shares 83,585 Value ($000) $86 Avg Close — Range —
Q4 2018
Shares 96,397 Value ($000) $41 Avg Close — Range —
Q3 2018
Shares 350,889 Value ($000) $744 Avg Close — Range —
Q3 2015
Shares 63,524 Value ($000) $657 Avg Close — Range —
Q1 2015
Shares 38,805 Value ($000) $253 Avg Close — Range —