VITAL THERAPIES INC

CUSIP: 92847R104 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 92,407 Value ($000) $18 Avg Close — Range —
Q4 2018
Shares 208,872 Value ($000) $39 Avg Close — Range —
Q3 2018
Shares 146,588 Value ($000) $40 Avg Close — Range —
Q4 2017
Shares 30,155 Value ($000) $179 Avg Close — Range —